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A detailed timeline outlining the key phases and experimental events in the study. Abbreviations: PND: Postnatal Day; NG: Naringenin; OFT: Open Field Test; EPM: Elevated Plus Maze; FST: Forced Swim Test; PFC: Prefrontal Cortex; DOPAC: 3,4 Dihydroxyphenylacetic Acid; (5-Hydroxytryptamine); 5-HIAA: 5 Hydroxyindoleacetic Acid; MAO-A: Monoamine Oxidase A; MDA: Malondialdehyde; SOD: Superoxide Dismutase; CAT: Catalase; TT: Total Thiol; Nit: Nitrite; GFAP: Glial Fibrillary Acidic Protein; <t>BDNF:</t> Brain-Derived <t>Neurotrophic</t> Factor; IL-10: Interleukin-10; NSE: Neuron-Specific Enolase.
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A detailed timeline outlining the key phases and experimental events in the study. Abbreviations: PND: Postnatal Day; NG: Naringenin; OFT: Open Field Test; EPM: Elevated Plus Maze; FST: Forced Swim Test; PFC: Prefrontal Cortex; DOPAC: 3,4 Dihydroxyphenylacetic Acid; (5-Hydroxytryptamine); 5-HIAA: 5 Hydroxyindoleacetic Acid; MAO-A: Monoamine Oxidase A; MDA: Malondialdehyde; SOD: Superoxide Dismutase; CAT: Catalase; TT: Total Thiol; Nit: Nitrite; GFAP: Glial Fibrillary Acidic Protein; <t>BDNF:</t> Brain-Derived <t>Neurotrophic</t> Factor; IL-10: Interleukin-10; NSE: Neuron-Specific Enolase.
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A detailed timeline outlining the key phases and experimental events in the study. Abbreviations: PND: Postnatal Day; NG: Naringenin; OFT: Open Field Test; EPM: Elevated Plus Maze; FST: Forced Swim Test; PFC: Prefrontal Cortex; DOPAC: 3,4 Dihydroxyphenylacetic Acid; (5-Hydroxytryptamine); 5-HIAA: 5 Hydroxyindoleacetic Acid; MAO-A: Monoamine Oxidase A; MDA: Malondialdehyde; SOD: Superoxide Dismutase; CAT: Catalase; TT: Total Thiol; Nit: Nitrite; GFAP: Glial Fibrillary Acidic Protein; <t>BDNF:</t> Brain-Derived <t>Neurotrophic</t> Factor; IL-10: Interleukin-10; NSE: Neuron-Specific Enolase.
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A detailed timeline outlining the key phases and experimental events in the study. Abbreviations: PND: Postnatal Day; NG: Naringenin; OFT: Open Field Test; EPM: Elevated Plus Maze; FST: Forced Swim Test; PFC: Prefrontal Cortex; DOPAC: 3,4 Dihydroxyphenylacetic Acid; (5-Hydroxytryptamine); 5-HIAA: 5 Hydroxyindoleacetic Acid; MAO-A: Monoamine Oxidase A; MDA: Malondialdehyde; SOD: Superoxide Dismutase; CAT: Catalase; TT: Total Thiol; Nit: Nitrite; GFAP: Glial Fibrillary Acidic Protein; BDNF: Brain-Derived Neurotrophic Factor; IL-10: Interleukin-10; NSE: Neuron-Specific Enolase.

Journal: Current Research in Pharmacology and Drug Discovery

Article Title: Neuroprotective effects of naringenin on nicotine-induced anxiety and depression: Involvement of monoaminergic systems, oxidative stress, and neuroinflammation on male rats

doi: 10.1016/j.crphar.2025.100242

Figure Lengend Snippet: A detailed timeline outlining the key phases and experimental events in the study. Abbreviations: PND: Postnatal Day; NG: Naringenin; OFT: Open Field Test; EPM: Elevated Plus Maze; FST: Forced Swim Test; PFC: Prefrontal Cortex; DOPAC: 3,4 Dihydroxyphenylacetic Acid; (5-Hydroxytryptamine); 5-HIAA: 5 Hydroxyindoleacetic Acid; MAO-A: Monoamine Oxidase A; MDA: Malondialdehyde; SOD: Superoxide Dismutase; CAT: Catalase; TT: Total Thiol; Nit: Nitrite; GFAP: Glial Fibrillary Acidic Protein; BDNF: Brain-Derived Neurotrophic Factor; IL-10: Interleukin-10; NSE: Neuron-Specific Enolase.

Article Snippet: In addition, brain-derived neurotrophic factor (BDNF) was quantified using a specific BDNF ELISA kit from CUSABIO (Cat. No. CSB-E04504r, USA).

Techniques: Derivative Assay

Effects of Naringenin on Neuroinflammatory and Neurodegenerative Markers (A) GFAP levels; (B) BDNF levels; (C) IL-10 levels; (D) NSE levels. Data are expressed as mean ± SEM (n = 8). Significant differences: p < 0.05, ∗ p < 0.01, ∗∗ p < 0.001 vs. vehicle group; + p < 0.05, ++ p < 0.01, +++ p < 0.001 vs. nicotine group.

Journal: Current Research in Pharmacology and Drug Discovery

Article Title: Neuroprotective effects of naringenin on nicotine-induced anxiety and depression: Involvement of monoaminergic systems, oxidative stress, and neuroinflammation on male rats

doi: 10.1016/j.crphar.2025.100242

Figure Lengend Snippet: Effects of Naringenin on Neuroinflammatory and Neurodegenerative Markers (A) GFAP levels; (B) BDNF levels; (C) IL-10 levels; (D) NSE levels. Data are expressed as mean ± SEM (n = 8). Significant differences: p < 0.05, ∗ p < 0.01, ∗∗ p < 0.001 vs. vehicle group; + p < 0.05, ++ p < 0.01, +++ p < 0.001 vs. nicotine group.

Article Snippet: In addition, brain-derived neurotrophic factor (BDNF) was quantified using a specific BDNF ELISA kit from CUSABIO (Cat. No. CSB-E04504r, USA).

Techniques: